Based on the social party game Spyfall, DC Spyfall is an easy to learn party game that includes tricks, suspicions, probing questions and smart answers. At the beginning of each round, players receive a secret card that informs them of the group's location, one of twenty unique locations in DC, including Arkham Asylum, the Daily Planet, the Hall of Justice and S.T.A.R. Labs, except for one player who receives the Joker's card instead. The Joker doesn't know where he is, but if he can find out his location before his cover is blown, he wins the round!

MIJAME includes some turns in the Spyfall formula. Since Harley Quinn usually follows the Joker around, each round a player may receive a location card with a picture of Harley on it; if he does, try to give the Joker's player location information, even if he doesn't know the identity of that player! If the Joker's player guesses the location, the two contributors each earn points, unless the superheroes can turn the tables and determine who Harley is.

The game includes two multi-verse decks containing eight different locations instead of just one, so players will get confused with some of the questions and answers. Keep in mind that no one at the table knows whether or not they are playing with a multi-verse deck. A deck of all the jokers gives each player one joker card, which means that all the questions and answers will be based on nothing more than what the players collectively create. As with a multiverse deck, you won't know you're playing with this deck until someone discovers it.

Super power cards can give a player a skill for a round, such as being able to dodge a question, or require a player to modify their behavior; for example, super speed forces a player to answer a question in three words or less.